Addiction to Methamphetamine

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Methamphetamine, a derivative of amphetamine, is a powerful stimulant that affects the central nervous system. Amphetamines were originally intended for use in nasal decongestants and bronchial inhalers and have limited medical applications, which include the treatment of narcolepsy, weight control, and attention deficit disorder. Methamphetamine can be smoked, snorted, orally ingested, and injected. It is accessible in many different forms and may be identified by color, which ranges from white to yellow to darker colors such as red and brown. Methamphetamine comes in a powder form that resembles granulated crystals and in a rock form known as "ice," which is the smokeable version of methamphetamine that came into use during the 1980s.

Effects

Methamphetamine use increases energy and alertness and decreases appetite. An intense rush is felt, almost instantaneously, when a user smokes or injects methamphetamine. Snorting methamphetamine affects the user in approximately 5 minutes, whereas oral ingestion takes about 20 minutes for the user to feel the effects. The intense rush and high felt from methamphetamine results from the release of high levels of dopamine into the section of the brain that controls the feeling of pleasure. The effects of methamphetamine can last up to 12 hours. Side effects include convulsions, dangerously high body temperature, stroke, cardiac arrhythmia, stomach cramps, and shaking.

Chronic use of methamphetamine can result in a tolerance for the drug. Consequently, users may try to intensify the desired effects by taking higher doses of the drug, taking it more frequently, or changing their method of ingestion. Some abusers, while refraining from eating and sleeping, will binge, also known as "run," on methamphetamine. During these binges, users will inject as much as a gram of methamphetamine every 2 to 3 hours over several days until they run out of the drug or are too dazed to continue use.

Chronic methamphetamine abuse can lead to psychotic behavior including intense paranoia, visual and auditory hallucinations, and out-of-control rages that can result in violent episodes. Chronic users at times develop sores on their bodies from scratching at "crank bugs," which describes the common delusion that bugs are crawling under the skin. Long-term use of methamphetamine may result in anxiety, insomnia, and addiction.

After methamphetamine use is stopped, several withdrawal symptoms can occur, including depression, anxiety, fatigue, paranoia, aggression, and an intense craving for the drug. Psychotic symptoms can sometimes persist for months or years after use has ceased.

Prevalence Estimates

According to the U.S. Department of Health and Human Services' Results From the 2002 National Survey on Drug Use and Health: National Findings, more than 12 million people age 12 and older (5.3%) reported that they had used methamphetamine at least once in their lifetime. Of those surveyed, 597,000 persons age 12 and older (0.3%) reported past month use of methamphetamine.

Since 1999, methamphetamine has been included in the University of Michigan's Monitoring the Future survey questionnaire. Survey results indicate that annual methamphetamine use (use within the past year) by secondary school students in 1999 ranged from 3.2% among 8th graders, to 4.6% among 10th graders, to 4.7% among 12th graders. In 2002, estimates of annual methamphetamine use ranged from 2.2% among 8th graders, to 3.9% among 10th graders, to 3.6% among 12th graders.

Consequences of Use

Chronic methamphetamine abuse can result in inflammation of the heart lining and, for injecting drug users, damaged blood vessels and skin abscesses. Social and occupational connections progressively deteriorate for chronic methamphetamine users. Acute lead poisoning is another potential risk for methamphetamine abusers because of a common method of production that uses lead acetate as a reagent.

Medical consequences of methamphetamine use can include cardiovascular problems such as rapid heart rate, irregular heartbeat, increased blood pressure, and stroke-producing damage to small blood vessels in the brain. Hyperthermia and convulsions can occur when a user overdoses and, if not treated immediately, can result in death. Research has shown that as much as 50% of the dopamine-producing cells in the brain can be damaged by prolonged exposure to relatively low levels of methamphetamine and that serotonin-containing nerve cells may be damaged even more extensively.

Methamphetamine abuse during pregnancy can cause prenatal complications such as increased rates of premature delivery and altered neonatal behavior patterns, such as abnormal reflexes and extreme irritability, and may be linked to congenital deformities. Methamphetamine abuse, particularly by those who inject the drug and share needles, can increase users' risks of contracting HIV/AIDS and hepatitis B and C.

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